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Serrapeptase
SUPPLEMENT FACTS


Serving size: 1 capsule
Servings Per Container: 90 servings
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                                                          Amount Per Serving            % DV
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Calcium (from Serrateric™)                        24.5mg                        2%
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Serrapeptase                                              40,000 Units                 †
     (serratiopeptidase activity units)
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† Daily Value not established.

Other Ingredients
: Cellulose, Serrateric™, modified cellulose (vegetarian capsule).

Suggested Adult Use
: Take 1 to 3 capsules daily, away from food, or as recommended by a nutritionally informed physician.

Non-GMO & Gluten Free

Serrateric™ is a trademark of Deerland Enzymes, Inc.
Serrapeptase is a proteolytic enzyme first isolated from the
non-pathogenic Serratiabacteria species strain E15 by Japanese researchers in 1966.1 Proteolytic enzymes, as the term implies, break down proteins. Serratia E15 was discovered in the Japanese silkworm, which harnesses serrapeptase enzyme activity to break down its cocoon walls.1,2 Each vegetarian capsule of Best Serrapeptase and Best High Potency Serrapeptase contains pure serrapeptase designed for optimal absorption in the intestinal tract.
Benefits
Promotes & Maintains Healthy Sinus and Airway Function*

Supports Healthy Immune Response*


The mucous membranes are a thin tissue layer or epithelium that lines the body’s hollow structures (cavities) opening to the exterior, such as the upper respiratory system. They secrete a slightly viscous fluid called mucus, which is actually a complex viscoelastic gel that lubricates and moistens the cavity surfaces. As a part of normal, healthy physiology, mucus is the first line of defense in the nose and lungs to trap and filter inhaled dust, pollutants, and other potentially damaging agents. Proteolytic enzymes such as
Serrapeptase
can break down inappropriate protein complexes in the mucus, thereby favorably influencing its properties and helping to support the healthy balance between adequate mucous viscosity/elasticity and airway comfort levels associated with the mucous membranes of the respiratory system.
3,4,5
Potency


Doctor’s Best discloses the potency details of
Serrapeptase
so you know exactly what you're getting. Enzyme strength is measured in terms of activity rather than weight, because an enzyme can be present but unless it is functional it will not be useful. Therefore, an enzyme product label should list the enzyme’s functional activity, and this usually will come from a laboratory measure as standard activity units. For serrapeptase the best standard measure is “Serratiopeptidase Units” or SPU.

To meet your individual needs, there are two levels of potency to choose from with
Best Serrapeptase
vegetarian capsules-either 40,000 or 120,000 SPU.

Best Serrapeptase has 40,000 SPU per capsule, which is considered a very high activity. Since Best High Potency
Serrapeptase
contains a tremendous 120,000 units, its suggested use is only 1 capsule per day.
* These statements have not been evaluated by the
Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent any disease
REFERENCES

1.Miyata K, Maejima K, Tomoda K, Isono M. Agr Biol Chem 1970;34:310-318.
2.Mecikoglu M, Saygi B, Yildirim Y, others. J Bone Joint Surg Am
    2006;88:1208-14.
3.Majima Y, Inagaki M, Hirata K, others. Arch Otorhinolaryngol 1988; 244:
355-9.
4.Majima Y, Hirata K, Takeuchi K, others. Am Rev Respir Dis 1990;141:79-83.
5.Shimura S, Okubo T, Maeda S, others. Biorheology 1983;20:677-83.
6.Kase Y, Seo H, Oyama Y, others. Arzneimittelforschung 1982;32:374-8.
7.Mazzone A, Catalani M, Costanzo M, others. J Int Med Res 1990;18:379-88.
8.Jadav SP, Patel NH, Shah TG, others. J Pharmacol Pharmacother
    2010;1:116-7.
9.Nakamura S, Hashimoto Y, Mikami M, others. Respirology 2003;8:316-20
What Is It?

•  Science-based nutrition
•  Dietary supplement

Serrapeptase is a proteolytic enzyme
isolated from the non-pathogenic bacteria
Serratia species found in the digestive tract
of the Japanese silkworm. The enzyme is
used by the worms to digest their cocoons.
Serrapeptase has been used as a nutritional
supplement in Europe and Asia for nearly
three decades. The serrapeptase is
formulated with Serrateric™, a superior
alternative to enteric coating that protects
the enzyme until it reaches the intestine for
optimal absorption.
Serrapeptase can also significantly affect sputum viscoelasticity.5,6 In an investigation of forty individuals who were randomly assigned to one of five groups, six participants were given serrapeptase for one week. Sputum viscoelasticity was analyzed using a rheometer and researchers concluded that serrapeptase altered the “relaxation behavior” of sputum - meaning
that serrapeptase helped support airway clearance.5

In a subsequent larger double blind trial, 193 participants were randomized into two groups and were instructed to take either serrapeptase or placebo 3 times daily after meals for one week.7 After 4 days and at the end of the 7-8 day period, mucus secretion, airway freedom, and measures of immune response were significantly favorable in the serrapeptase group compared with the placebo group. A recent study in which the immune system of rats was challenged further confirms human data that serrapeptase can be used for supporting the immune system.8

In a controlled and randomized open-label study of 29 subjects, researchers again observed the effects of Serrapeptase supplementation on sputum. After 4 weeks, subjects taking Serrapeptase had significantly less morning sputum with favorable viscoelasticity; furthermore, the serrapeptase group had fewer neutrophils in their sputum, signifying a more balanced immune response to maintain airway health.9
Research with Serrapeptase for maintenance of healthy sinus function began decades ago in Japan. Studies thus far indicate that serrapeptase
is a safe and useful supplement to promote favorable viscosity of nasal and bronchial mucus. Two of the earliest human trials found that serrapeptase had favorable effects on upper airway viscosity.3,4 In these assessments, mucus was collected from participants after a 4-week supplementation period and evaluated using an rheometer to determine its viscoelastic properties. The enzyme’s action most likely involves the breakdown of mucus protein structures, consequently allowing the cilia (microscopic hairlike projections in the mucosal epithelium of the upper respiratory tract) to helpfully transport mucus in the airway.
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Last modified June, 2015.
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