Best Acetyl-L-Carnitine (588 mg)

Science-Based Nutrition

Dietary supplement

Beneficial antioxidant protection*

Enhances alertness and mental focus*

Supports energy metabolism in the brain*

Keeps nerves healthy and in repair*

Decreases free radical production in
    the brain*

(

) is a naturally
occurring form of L-Carnitine, a vitamin-like
nutrient synthesized in the body from the amino
acids lysine and methionine.

plays a key
role in the production of acetylcholine, an
important neurotransmitter for brain and nerve
cell function.*

The

Acetyl-L-Carnitine in this product is derived from a base of pharmaceutical grade L-Carnitine manufactured by patented, FDA-approved process that fully complies with the USP 25, FCC 4 and EU monographs. It is GMO-free, pesticide-free and BSE safe.

Serving size: 1 capsule
Servings Per Container: 60 servings
                                                                     Amount Per Serving     %DV
-----------------------------------------------------------------------------------------------------
Acetyl-L-Carnitine                                                   500 mg                  †
(from 588mg acetyl-l-carnitine HCl
supplied by

)
-----------------------------------------------------------------------------------------------------
† Daily Value not established.

: Stearic acid, cellulose, magnesium silicate, silicon dioxide, gelatin (capsule).

: Take 1 to 4 capsules daily with or without food. Higher intakes may be beneficial, as recommended by a nutritionally
informed physician. Individuals with thyroid problems or on anticoagulant therapy should consult their physician before using this product.

(

) is a naturally occurring form of L-Carnitine, a vitamin-like nutrient synthesized in the body from the amino acids lysine and methionine.

serves as a transport molecule for “active acetate,” which is a source of fuel for metabolic processes that take place in cells.

carries active acetate (the “Acetyl” portion) directly into the mitochondrion, the cell’s energy-generating structure. Active acetate is used to produce cellular energy in the form of ATP. Both L-Carnitine and

serve as fat carriers. Unlike L-Carnitine,

readily crosses the blood-brain barrier, where it has specific benefits for brain neurons. When taken orally,

has been shown to promote healthy

levels in both blood and cerebrospinal fluid, demonstrating its uptake in the brain.

contains Biosint™ Acetyl-L-Carnitine, which is manufactured in Italy by the reputable company

. It is derived from a base of pharmaceutical grade L-Carnitine manufactured using an FDA approved process that fully complies with international monograph standards for carnitine production. Known as a global leader in L-Carnitine research, Sigma-Tau holds numerous patents for production of L-Carnitine, the derivatives of which are used in clinical trials.

has been studied for its effect on cognitive performance and emotional health in the elderly. In a single-blind, placebo-controlled trial, 481 elderly subjects taking 1500 mg of

per day were found to have improved scores on a memory test assessing cognitive abilities after 90 days of

supplementation.

In addition to being known for its effects on recognition and memory, placebo-controlled

research has also shown better scores in scales measuring the mood of elderly people.

Brain function requires coordinated communication between brain cells. Neurons (brain & nerve cells) communicate across tiny cell-to-cell gaps called synapses. The passage of an electrical impulse from one neuron to the next requires a neurotransmitter to act as a messenger to pass signals to adjacent neurons. When an electrical signal arrives at the synaptic junction, the neuron releases a neurotransmitter into the synapse. The neuron on the other side of the synapse contains receptors for the neurotransmitter (that will bind it), triggering a series of chemical events to send a new electrical signal down the membrane of the receiving neuron. Neurotransmitters work together like an orchestra to transmit information throughout the brain and nervous system.

Acetylcholine is the most abundant neurotransmitter in the body, regulating activities of vital organs and blood vessels, and communication between nerves and muscles. In the brain, acetylcholine helps to facilitate memory and learning, as well as influencing emotions.

is structurally similar to acetylcholine- enough so that brain neurons stimulated by acetylcholine are receptive to stimulation by

.

In an experimental animal model, it was shown that

can furnish acetyl groups to be utilized during the natural biosynthesis of acetylcholine.

’s structural similarity to acetylcholine has led researchers to investigate its effects on mental function and emotional health.

The acetyl groups donated by

can be used to naturally synthesize acetyl-CoA, the key substrate for energy metabolism in the mitochondrion.

Acetyl-CoA enters the Krebs cycle, the mitochondrial pathway that generates cellular energy in the form of ATP. Age-related decreases in mitochondrial oxidative capacity are a well-known cause of aging, as the organelles and organs in the body begin to operate less efficiently without ideal ATP production. The effects of decreased mitochondrial oxidative capacity are especially prevalent in organs that require high-energy inputs, such as the brain and heart. Recent clinical studies have shown that

helps to promote and maintain healthy mitochondrial function.

Phospholipids are structural components of brain cell membranes that regulate neuronal function.

has been shown to promote healthy membrane phospholipid metabolism in research subjects.

Additionally, the acetyl groups in

are naturally utilized by the body to modify the activity of proteins in neuronal membranes.

Through these means,

promotes normal membrane function, stability, and structural integrity.

The body produces specialized proteins called growth factors that are essential to the growth and repair of tissue. Nerve Growth Factor (NGF) prolongs the survival of neurons in both the central and peripheral nervous systems. As we age, our central nervous system experiences a decrease in the binding of NGF to neuron membranes.

has shown the ability to promote the maintenance of normal interactions between NGF and neuron membranes.

Given to aged rats,

demonstrated effectiveness in promoting normal levels of NGF, and it helped maintain utilization of the growth factor in the rats throughout the duration of the study. Maintaining ideal levels of NGF is essential for the health of cholinergic neurons (nerve cells stimulated by acetylcholine), as cholinergic neurons lose some functional capacity due to a lack of NGF. In aged rats,

is known to promote the health of cholinergic neurons.

In sum, such results suggest that

positively influences the maintenance of healthy and normal NGF activity.

Several animal studies have revealed that

contains many biochemical characteristics that help neurons face the aging process optimally.

has been shown to raise levels of glutathione, a key antioxidant, in isolated mouse brain tissue.

also reduces blood levels of MDA (malondialdehyde), a free radical byproduct.

Furthermore,

is a
chelator of iron: it acts as a molecule that can naturally sequester iron in the body to prevent iron-mediated oxidative damage to cells.

As a whole, data from in vitro and animal studies suggest that

is effective towards the maintenance of healthy brain neurons and normal neuronal energetic processes. This hypothesis is supported by human studies that demonstrate the potential of

to promote healthy brain function in elderly persons.

Acetyl-L-Carnitine (

) is a naturally occurring form of L-Carnitine, a vitamin-like nutrient synthesized in the body from the amino acids lysine and methionine.

serves as a transport molecule for “active acetate,” which is a source of fuel for metabolic processes that take place in cells.

carries active acetate (the “Acetyl” portion) directly into the mitochondrion, the cell’s energy-generating structure. Active acetate is used to produce cellular energy in the form of ATP. Both L-Carnitine and

serve as fat carriers.

Unlike L-Carnitine,

readily crosses the blood-brain barrier, where it has specific benefits for brain neurons. When taken orally,

has been shown to promote healthy

levels in both blood and cerebrospinal fluid, demonstrating its uptake in the brain.1 Best Acetyl-L-Carnitine contains Biosint™ Acetyl-L-Carnitine, which is manufactured in Italy by the reputable company

. It is derived from a base of pharmaceutical grade
L-Carnitine manufactured using an FDA approved process that fully complies with international monograph standards for carnitine production. Known as a global leader in L-Carnitine research,

holds numerous patents for production of L-Carnitine, the derivatives of which are used in clinical trials.